He Who Cast The First Stone
He Who Cast The First Stone is a challenge added into Wave 5 of the Epiphany mod. The player character is 
Tarnished Samson, who must defeat 
Isaac. Completing the challenge unlocks 
Revolt.
Difficulty
- Tarnished Samson is unable to punch in this challenge, so he is completely reliant on his slam, rocks, and
Killer Instinct in order to damage enemies. With a vital part of Samson's arsenal removed, this makes this challenge quite difficult if the player is unfamiliar with his other tools. - Samson charges the slam attack twice as fast in this challenge
Strategy
Without any punches, Tarnished Samson should not be as close to enemies as he normally would be, though it's still recommended to be slightly close to them in order to make the most of his slam and Killer Instinct. Samson's boulders will often be his most useful tool in this challenge, giving a good mixture of both range and damage output, but does have the drawback of taking a considerable amount of time to create them, leaving Samson vulnerable. As such, items that modify Samson's boulders become more important than ever.
With the lack of a quick method to rack up damage, Immortal Rage should be avoided, as it's more than likely to cause Samson to die if he does not fill his Slaughter Bar quickly, and the benefits it gives are limited anyways, given Samson's lack of punching.
Range and Tear increases aren't as useful in this run, as well as tear effect items. 
Birthright mainly affects Immortal Rage, and could be avoided too
| Challenges | |
|---|---|
| Wave 4 |  Sweet Tooth ·  NullPointerException ·  One With Nothing ·  Kagemane no Jutsu ·  Pool!
|
| Wave 5 |  Dealmaker · Overwhelming Odds · He Who Cast The First Stone
|
| Wave 6 |  Retribution
|