Pickups

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Pickups
Broken heart pickup.png Hearts Tastypenny.png Coins Multitool.png Keys Cardback.png Cards Essence of Isaac.png Essences Capsule d6.png Dice Capsules Dusty Chest.png Chests

Pickups are minor consumable items found throughout the game. These includes hearts, coins, keys, bombs, cards and pills.

Epiphany adds several new pickups unlocked by obtaining Achievements as Tarnished characters, completing Challenges, or are simply spawned by other items.

All pickups in Epiphany are listed here. For further information on a specific pickup, refer to the pages listed above.

Pickup Image Effect How to Find Unlock
Broken Heart
Broken heart pickup.png
Gives a Broken Heart on pickup. Can only be created by the R Queen of hearts.png Queen of Hearts? and True love.png True Love. N/A
Tasty Penny
Tastypenny.png
Gives a penny if at full health.

If not, heals one HUD heart red full.webp instead

2% chance to replace a penny. Complete Pool!
Multitool
Multitool.png
Can be used to unlock any non-story locked door, chest or secret room, even those not normally opened with keys 2% chance to replace a key. Defeat Mega satan.webp Mega Satan as Tarnished cain small.pngTarnished Cain
Queen of Hearts? R Queen of hearts.png Spawns 12 broken hearts on use. Any broken hearts taken grant a permanent damage up. Entering a new floor removes 1 broken heart given by the card Is a type of Card. Defeat Ultra Greedier as Tarnished maggy small.png Tarnished Magdalene
Two of Suits? Two of spades.png Two of clubs.png
Two of diamonds.png Two of hearts.png
Halves your amount of the selected consumable type and adds a third of the removed number to every other consumable type. Is a type of Card Defeat Ultra Greedier as Tarnished judas small.png Tarnished Judas
Essence of Isaac Essence of Isaac.png Removes 1 item of player's choice from their inventory and spawns 3 item pedestals, only one of which can be taken. Spawned item's quality have a chance to be higher or lower than the consumed item's. Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished isaac small.pngTarnished Isaac
Essence of Magdalene Essence of Magdalene.png Fires a barrage of Cardiac Arrest shots. Damage of each shot increases as the barrage approaches its end. Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished maggy small.pngTarnished Magdalene
Essence of Cain Essence of Cain.png Reseals every chest and fixes every broken slot machine in the room. Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished cain small.pngTarnished Cain
Essence of Judas Essence of Judas.png Turns up to 2 item pedestals in the room into a choice between an angel and a devil item. Taking one gives the player 2 broken hearts. Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished judas small.pngTarnished Judas
Essence of Samson Essence of Samson.png Deals fake damage a random amount of times from 4 to 7, increasing the player's damage by +0.30 per hit for the rest of the floor. Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished samson small.pngTarnished Samson
Essence of Eden Essence of Eden.png Converts pedestals in the room into an item that rerolls every room into the same quality, similar to Tarnished Eden's mechanic. Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished eden small.pngTarnished Eden
Essence of The Keeper Essence of Keeper.png Goldifies the room and applies a Midas Touch effect to all enemies in the room, lowering the player's luck for each one (-2 per item, -1 per trinket, -0.25 per pickup). Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished keeper small.pngTarnished Keeper
Essence of The Lost Essence of Lost.png Rerolls every pedestal item in the room and increases their quality, but each item has a 50% chance to disappear. Is a type of Rune Defeat Bossrush.png Boss Rush and Hush.pngHush as Tarnished lost small.pngTarnished Lost
Bagged Essence Bagged essence.png Uses the associated character essence. If the character doesn't have any essence associated, it uses a random one. Is a type of Rune Use 20 Essences
Dice Capsules Capsule d6.png Uses the associated Dice collectible. Dice machine.pngDice Machines Defeat Mega Satan as Tarnished isaac small.pngTarnished Isaac
Dusty Chest
Dusty Chest.png
Can be unlocked for a HUD heart soul full.webp soul heart and commonly drops nickels or essences. Is a type of Chest Defeat Mega satan.webp Mega Satan as Tarnished lost small.pngTarnished Lost