Challenges

Challenges are special runs which implements a unique condition to it, whether it be granting the player a set of starting items and/or giving them a handicap in some way.

The Epiphany mod introduces 8 new Challenges into the game as of Wave 5, with the completion of each one rewarding the player with an unlock.

Challenge	Character	Unlock	Goal
Sweet Tooth		Mom's Hug	Mom's Heart
NullPointerException		Drawn Card	Mom's Heart
One With Nothing		Nothing	Isaac
Kagemane no Jutsu		Thirty Pieces of Silver	The Lamb
Pool!		Tasty Penny	The Lamb
Dealmaker		Coin Case	The Lamb
Overwhelming Odds		Chance Cube	Mom's Heart
He Who Cast The First Stone		Revolt	Isaac
Retribution		Retribution	Mom's Heart